Alzheimers
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What causes Alzheimer's Disease (AD)?
New information shows there is inflammation & active immune processes in Alzheimer's patients brains.
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TITLE: Brain Tissue Inflammation Drives Alzheimer's Disease
https://www.upmc.com/media/news/082621-pascoal-alzheimer
Together with amyloid plaques, the presence of the following are observed in Alzheimer's disease:
The immune system protects the body via
1. lymphocytes – white blood cells of many types- macrophages, microglia, T cells, plasma cells, etc.
2. Humoral Immunity - involving chemokines in the humors or fluid part of the blood.
In other diseases such as Rheumatoid arthritis, both the lymphocytes and humor immunity are involved, but comparing this to AD, lymphocytes do not attack brain or cells.
Research found activity by complement; Complement are proteins – our immune system produces them and they are good at attacking and destroying invading microorganisms including viruses. Normally complement are safe and do not cause problems or damage to the brain. But in Alzheimer's disease the complement is implicated to start the attack.
The following are observed in Alzheimer's disease:
2. Complement protein ( immune reactive factors )- have names beginning with C for example C1, C3, C7
3. microglia and macrophages – blood cells which are normal parts of the immune system . Microglia are known as resident lymphocytes , these cells stay within the regions of the brain & act as protection against all pathogens, germs, bacteria, fungi & viruses.
4. Astrocytes – part of the brain cells.
Complement – there are several of them but together they are effective at killing and destroying bacteria and other microorganisms. If one were to observe complement at work , they usually attach to the cell walls of for example bacteria and form tiny holes or breaks on the walls.
But complement is unique because when it acts, there are several of these holes and they do not close nor repair. When that happens to bacteria, the holes or breaks leads to leaking of the contents of the cell and that cell is doomed and eventually dies.
view
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724661/
One strategy suggested by medical research is to treat AD using Complement Inhibitors.
But that therapy will not work for 2 reasons.
First, the macrophages, microglia and even astrocytes which are on areas that the Alzheimer's condition starts also produce complement.
Second, the Alzheimer brain apparently mounts a defense against chronic complement attack.
The following are Complement Inhibitor factors:
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clusterin
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C1-inhibitor
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lactoferrin
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C4 binding protein
All 4 above are upregulated in AD. As mentioned, the brain does produce these Complement inhibitors but it does not fix the problem
Higher levels of these Complement inhibitors are found in the AD brain, C1-inhibitor is detected in its cleaved form in AD.
Presence of the cleaved form, therefore, indicates that C1 has been activated and then inhibited by the C1-inhibitor.
Since these do not prevent the disease, there is a need to find other methods to remedy AD..
What exactly is being attacked by the immune system?
It is the vimentin in neurons.
The 2 articles below points to the protein vimentin which is the target antigen in Alzheimer's Disease.
Other journals also states vimentin is attacked in AD but 2 should be sufficient to prove
our point.
https://www.nature.com/articles/s41598-019-48329-4
https://link.springer.com/article/10.1007/BF00311389
Lastly, below are research articles which proves the presence of antibodies in Alzheimer's Disease.
https://journals.sagepub.com/doi/pdf/10.1177/153331750502000303
file:///C:/Users/CPS-216/Downloads/01.STR.23.8.1078%20(1).pdf
https://pubmed.ncbi.nlm.nih.gov/2974704/
Complement can be present in the blood and even in high levels but should not pose problems to the host since it normally appears in an inactive form.
What activates Complement?
There are 3 pathways
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Classical pathway
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alternative pathway
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mannose binding pathway.
For the explanation, we should only consider Classical pathway because it is the one that is involved in the case of Alzheimer's disease. It is Antibodies – specially Immunoglobulin G and Immunoglobulin M. When antibodies attaches or binds to an antigen, it becomes an Antigen-Antibody complex & changes and is the kind that will activate complement if complement is present.
Our article here explains all 3 are present – vimentin – antibody and complement. The complement starts destruction of brain cells and that is how alzheimers disease starts and progresses.
How do these all relate to the amyloid?
GFAP and Vimentin surround a core which is amyloid in astrocyte cells. The immune attack is on vimentin which releases its covering and the amyloid. The amyloid is not attacked and accumulates as debris.
The Immune System has its own controls:
1. Helper T cells functions to increase antibody production.
2. Suppressor T cell or Regulatory T Cells - gives the signal to lower antibody production.
If a method were found that is able to harness the T Reg cells, it will be the solution to so many autoimmune diseases.
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https://en.wikipedia.org/wiki/Regulatory_T_cell
This site states Regulatory T Cells form part of the immune system that modulate the immune system, maintain tolerance to self-antigens and prevent autoimmune disease.
How to harness the T Reg Cell
The way to use T Reg cell - the method is Immune Tolerance and Oral Tolerance.
Immune Tolerance means tolerating Antigens instead of attacking them.
Oral tolerance is the suppression of immune responses to antigens (Ag) that have been administered previously by the oral route. Multiple mechanisms of tolerance are induced by oral Antigen. Low doses favor active suppression, whereas higher doses favor clonal anergy/deletion.
Oral Tolerance is successful in Animals
View link- Success in Animals trials below:
https://books.google.ca/books?id=FsGMEOhNEqMC&pg=PA215&lpg=PA215&dq=oral+tolerance+animal+successful&source=bl&ots=2kzRFQLF0i&sig=S_QV_foYEyvOy_GIB44fxW5Wx-A&hl=en&sa=X&ved=2ahUKEwjG89WanfjdAhVLwlQKHdL5BAIQ6AEwCHoECAAQAQ#v=onepage&q=oral%20tolerance%20animal%20successful&f=false
But Oral Tolerance is not successful in humans.
The way to Success is a new discovery which is B7.
The Research by Dr. Polly Matzinger explains the T cells requirements.
The T cell needs 2 factors or signals for full activation.
1.) a peptide of the target antigen - vimentin, – the dose primes or makes ready the T cell. But without the 2nd signal the T cell remains in anergy ( no activity).. If vimentin is accepted by the T Reg cell, it will lower antibodies specific to vimentin ONLY. It is very specific.
2.) the Second signal is co-stimulation –which is B7 also known as CD80 (B7-1) & CD86(B7-2) – either one is enough to make the T cell go through the changes that makes it a fully activated cell.
Second Signal or Co- stimulation is explained at
https://en.wikipedia.org/wiki/Co-stimulation
Dr. Matzinger’s discovery is called Danger Theory because methods available to Modern Medicine to induce B7 were Vaccines, Toxoids & byproducts from dangerous micro-organism & not applicable due to toxicity including inflammatory lymphokines, fevers, fatigue from an overactive immune system ..
But Dr. Matzinger was not aware there is a nontoxic and safe method to induce B7 and that is through Herbs.
However, Modern Medicine has the policy of not including herbs with their drugs. They feel that herbs are cheap and cheap means little or no profit.
One last problem – Herbs that induce B7 by lymphocytes also induce Inflammation by lymphokines – Interferon, Interleukin 6 & Tumor Necrosis Factors. Inflammation leads to more Antibodies which results in failure. The problem is fixed by a 2nd herb that minimizes inflammation.
At this point, a successful formula is possible combining Oral Tolerance and 2 herbs – the 1st for B7 induction and the 2nd to inhibit production of inflammatory lymphokines.
How the formula works.
Oral Tolerance leads to proliferation of new Suppressor T cells, the new cells work against Helper T cells which delete each other, when Helper T cells are reduced, high antibodies to vimentin go down to normal, each course leads to improvement until complete healing.
If people need to decide whether to use herbs with Modern Medicine methods, we need to explain that actually there is one Branch of Modern Medicine that already includes herbs and this is with Stem Cell Therapy. In fact, if anyone looks over the advances in Stem Cell therapy, one will find simple supplement drugs and all of them from herbs because herbs are the only possible nontoxic chemicals.
We call our formula the T Cell Therapy - the reason is everytime someone reads on Oral Tolerance, it is not successful on humans, therefore T Cell Therapy is our treatment and is successful.
Lux Research – a division of Lux Health Resources has done the research.
The healing rate is 68% - with 47% achieved total healing and 21% reporting partial healing. That 47% and 21% of healing are positive results considering these are for autoimmune cases where modern medicines are not effective.
The herbs take only 6 days for each course of treatment followed by 15 days of transition – meaning the body makes the necessary changes.
For moderate cases – about 9– 12 courses.
For severe cases – 13 – 17 courses of treatment.
Is Oral Tolerance safe therapy for illness?
Yes, Dr. Howard Weiner, an authority on Oral Tolerance stated it is safe & good for treating autoimmune diseases.
See article
https://www.nytimes.com/1994/10/18/science/hair-of-dog-tried-as-cure-for-autoimmune-disease.html
Peptide Antigen (one Oz.=about 30 ml. & enough Herbs for 4 courses treatment.
Cost for the complete formula above.
Adults - UP to 99 lbs- $109
100 to 120 lbs-$129121 to 140 lbs-$149
141 to 160 lbs-$169
161 to 180 lbs-$189
181 to 200 lbs-$209
201 to 220 lbs-$229
221 to 240 lbs-$249
241 to 260 lbs-$269
Add Shipping to to U.S. - $20 USD
For International countries $ 30 USD
DIRECTIONS FOR TAKING FORMULA:
1. Exercise is ok but not excessive exercise
2. If you get infections, no treament until the infection is over
3. No surgery -operations can change the body, no treatment
no damage to body or injuries of any sort, accidents - please wait until your body is well.
4. No smoking - Research has found that smoking always leads to more inflammation.
5. The following herbs or medicines should not be taken:
All kinds of drugs for diabetes specially metformin.
Berberine - from herbs - acts similar to metformin.
Euphorbia hirta - herb
Aspirin is allowed but not more than 4 tablets a day.
IBuprofen - similar o aspiring - not more than 4 pills a day.
H2 histamine inhibitors - should be avoided
Ranitidine (Zantac)
Cimetidine - known to increase antibodies .
Foods - spicy foods - chilis, peppers, ginger - okay but eat in moderation.
We will be adding more to these list.
If you take any medications, supplements, herbs . kindly
write to us since we need to make sure there are no problems.
People who reach old age -60 stop producing thymus hormone - it is important with our formula.
If you are 55 years or younger, you do not need thymus hormone.
57 years and older may need thymus hormone.
However, we found one company from Germany that supplies the complete thymus hormones - there are several and their product is Thymrevit from
https://www.medpex.de/thymrevit-revitalisierungskapseln-10-mg-p1696067
Do not order the 1 mg. which is for children, the adult pills are 10 mg. However, if your age is close to 60, you may not be producing enough hormone for a successful therapy.
Thymrevit is not available. However, Thymuskin is made by the same company. Although Thymuskin is a treatment for hair to grow, actually it is the same drug. This can be used as a substitute for Thymrevit, however the manufacturer stated it is only to be applied on
skin because it is not possible orally. They also stated they might make Thymrevit next year. In the meantime, thymuskin is a substitute
and the active ingredients including the peptide will be absorbed through the skin. We can advise regarding the dose.
To order our product, please use button below:
Questions or Comments, please contact us.
Contact person:
David Koenig or Henry
email: kimberlite36@yahoo.ca
tel. # [ 778] -3818143
Lux Health Resources
11068 131A St.
Surrey, British Columbia V3T 3R9
Canada